A CANNONVALE man is among five people who have been refused bail after police seized about 50,000 cannabis seeds and hundreds of thousands of dollars of suspected stolen property.

Police executed search warrants in the Townsville, Cairns and Mareeba regions as part of a major 16-month operation targeting an alleged large-scale drug operation.

Investigators executed six search warrants last week.

Detective Acting Senior Sergeant Adam Golding said the investigation, codenamed Kilo Enhance, would make a dent in the supply of drugs around Queensland.

"This was a major investigation targeting serious organized crime," he said.

"Drugs have a devastating impact on our communities and these 50,000 cannabis seeds had the potential to supply drug markets across the state."

"Investigators from Cairns, Townsville and Mareeba have worked for well over a year as part of Kilo Enhance."

A number of other suspected stolen property worth around $175,000, including tractors and other large farm machinery, a four-wheel drive and multiple weapons, were also recovered from the properties.

Police have charged at least eight men with more than 100 offences including more than 75 counts of possessing or supplying a dangerous drug, and multiple weapons and property-related offences.

Five of the alleged offenders, a 44-year-old Cannonvale man, a 54-year-old Nome man, a 46-year-old Biboohra man, a 46-year-old Stuart man and a 20-year-old Mooroobool man have been refused bail.

They are expected to appear in Townsville and Mareeba Magistrates Courts in the coming months.